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Threshold of Toxicological Concern – EFSA meets stakeholders

The European Food Safety Agency (EFSA) and the World Health Organization (WHO) will convene a stakeholder event in December on specific questions on the science and concept of Threshold of Toxicological Concern (TTC).

EFSA and WHO aim to develop a globally harmonised decision tree for a tiered approach on the application of the TTC in the risk assessment of chemicals, based on the current state-of-the-science and building on existing work.

The TTC is a tool that provides conservative, screening-level exposure limits based on information on chemical structure in the absence of sufficient chemical-specific toxicological data. It is an important science-based approach for prioritising those chemicals with low-level exposures that require more data over those that can be presumed to present no appreciable human health risk.

Since its original development and application in the food area, further scientific developments have taken place leading to the need for a critical review and possible update of the TTC approach.

To gain the broadest possible input, EFSA and the WHO will convene a stakeholder meeting on 2 December 2014 in Brussels which will then be considered in the subsequent expert meeting from 3 – 5 December as well as future activities. Here, international experts will aim to agree a consistent and globally accepted science based TTC approach. A call for experts for the EFSA/WHO expert meeting has been launched and is available on the WHO website.

You can find more information here.

Originally posted on 25 September 2014

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